Date published: 01.09.08 - not release date

Pycnogenol® Reduces Diabetic Microangiopathy

Study Reveals 68 Percent Improvement of Blood Flow

Diabetic microangiopathy is responsible for major diabetic health complications, such as leg ulcers, kidney failure and retinopathy. It is imperative diabetics receive the best treatment to manage this condition. A study published in the September edition of Angiology shows that Pycnogenol® (pic-noj-en-all), an antioxidant plant extract from the bark of the French maritime pine tree, significantly reduced diabetic microangiopathy (DM) in patients after supplementing with Pycnogenol®.

“Diabetic microangiopathy is not a rare phenomenon and essentially affects every diabetic person. The condition may result in vision loss in diabetic retinopathy, kidney problems and ischemic tissue necrosis causing leg ulcers which may lead to amputation,” said Doctor. Gianni Belcaro, a lead researcher of the study. “With DM, the walls of very small blood vessels (capillaries) become so weak, bleeding and protein leaks occur, which ultimately slows down blood flow, resulting in blood clots and swelling of the limbs (edema).”

The study sampled 60 diabetic patients suffering from DM being treated with insulin for at least three years at the Chieti-Pescara University in Italy. In addition to their insulin treatment, patients received 150 mg of Pycnogenol® orally daily for one month. The control group, 50 percent of the sample, received a placebo. Measurements of blood flow were measured by laser Doppler.

Measurements were taken when patients were lying down and standing up. The capillary adaptation to increased pressure from lying down to standing is generally impaired, due to vessel failure and increase of pressure in capillaries for individuals who suffer from DM.

Results showed that when patients were lying down, Pycnogenol® treatment improved capillary blood flow by 34 percent, compared to 4.7 percent in the placebo group. When patient’s blood flow was measured in a standing position, Pycnogenol® treatment improved capillary blood flow by 68 percent, compared to 8 percent in the placebo group.

Capillary leakage was recorded by measuring ankle swelling, which develops ten minutes after passing from lying down to standing up. After Pycnogenol® treatment, swelling was 17 percent lower, compared to 2.6 percent in the placebo group.

“The rapid improvement of microvessel complication with Pycnogenol® in just four weeks is clinically remarkable,” said Doctor. Belcaro, who has been a large part of previous Pycnogenol® and diabetes related studies.

In July, a study was published supporting diabetic foot ulcer treatment with Pycnogenol®. Results revealed almost 75 percent decrease is ulcer size in patients who supplemented with both oral and local Pycnogenol®. Previous research supports Pycnogenol® treatment to be highly effective for prevention of diabetic retinopathy and to be effective in lowering glucose levels and increasing the health of blood vessels in patients with type II diabetes. Previous research may be found at www.pycnogenol.com.


Pycnogenol® is a natural plant extract originating from the bark of the Maritime pine that grows along the coast of southwest France and is found to contain a unique combination of procyanidins, bioflavonoids and organic acids, which offer extensive natural health benefits. The extract has been widely studied for the past 35 years and has more than 220 published studies and review articles ensuring safety and efficacy as an ingredient. Today, Pycnogenol® is available in more than 500 dietary supplements, multi-vitamins and health products worldwide. For more info or a copy of this study, visit www.pycnogenol.com.

Issued by:Pegasus Public Relations
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Press enquiries:Sallyanne Jones/Kate Allan (01903) 821550
Email:kallan@pegasuspr.co.uk


Ref: 7924October 2006